Petrigliano Research Lab

The basic focus of Dr. Petrigliano’s Lab is the study of the underpinnings of muscle atrophy and degeneration following large rotator cuff tears.

Following rotator cuff repair, muscle atrophy and fibrosis may result in persistent weakness and increase the risk of repair failure. Consequently, our team is studying cutting-edge approaches to improve rotator cuff function via the delivery of stem cells that are specialized to restore muscle after chronic injury.

This work has been funded by the National Institutes of Health (NIH) and the Orthopaedic Research and Education Foundation (OREF), and a recent study was awarded the Charles S. Neer Award in recognition of outstanding work in the field of shoulder research. We also work in close collaboration with the Eveseenko Lab at the USC developing small molecule and stem cell-based therapies to treat osteoarthritis.

The goal of our work is to provide novel treatments that improve function and decrease the risk of arthritis after shoulder injury.

If you are interested in learning more about the lab, or participating in our work, please contact Dr. Petrigliano at Frank.Petrigliano@med.usc.edu.