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Orthobiologic Injections

Orthobiologic injections contain constituents that are derived from naturally occurring substances in the human body, such as proteins or hormones. These substances can help to reduce inflammation, treat pain, and promote tissue healing and regeneration. The use of orthobiologics is often referred to as regenerative medicine.

What are orthobiologic injections?

Orthobiologic injections are treatments that can help relieve pain and improve function in people with conditions affecting the bones, muscles, and joints.

Orthobiologic injections are usually injected into the joint. They can also be injected into tendons, ligaments, or bursae (fluid-filled sacs that cushion and lubricate joints).

What conditions can orthobiologic injections treat?

Orthobiologic injections can be used to treat a variety of conditions, including:

  • Arthritis
  • Bursitis
  • Tendinitis
  • Rotator cuff injury
  • Ligament and tendon injury

What are the benefits?

  • Reduced pain
  • Improved function
  • Increased range of motion
  • Decreased inflammation
  • Faster healing time
  • Improves healing in tissues with limited blood supply

What are the most used orthobiologics?

Hyaluronic acid (HA)

HA is made naturally by the body to retain water to keep tissues moist and lubricate the joints, skin, and eyes. HA is an important component of articular cartilage that lines the ends of the bones. HA also promotes the growth and development of new cells and tissues. Often called “viscosupplementation”, injections of HA treat arthritis knee pain by increasing the amount of HA in the joint.  Before the injection, Dr. Petrigliano will inject local anesthetic to numb the sensation of the needle injection. Side effects may include soreness at the injection site.

Platelet Rich Plasma (PRP)

PRP is made from your own blood that is prepared to deliver platelet-derived growth factors and proteins in high concentrations for cellular therapy. A small amount of your blood is drawn, spun, and processed to create a serum of concentrated platelet growth factors and proteins. Platelets are the body’s tool to naturally heal and grow new cells to rebuild your tissues. The serum stimulates the growth of new tissues.  The benefits of PRP occur gradually over the course of three to six months. Results can last up to 2 years.

Bone Marrow Aspirate Concentrates (BMAC)

BMAC are made from the cells in your bone marrow and are used to initiate healing. The bone marrow is obtained during an outpatient procedure by extracting a small amount of marrow from the hip, under local anesthesia. The aspirate is spun in a centrifuge to concentrate proteins called growth factors and stem cells that can regenerate tissues. BMAC is particularly helpful to treat tissues that have a limited natural blood supply. They are used to treat moderate to severe orthopedic injuries and to treat arthritis of shoulder knee and hip. However, they have been successfully used to treat tennis and golf elbow, meniscus tears, rotator cuff tendinitis, Achilles’s tendinitis, and low back pain from herniated discs. It may take 6-8 weeks for the full effects are experienced.

Schedule a consultation

Orthobiologics represent state-of-the-art treatments for pain relief and tissue repair. Dr. Petrigliano is the chief of sports medicine at the Epstein Family Center for Sports Medicine at Keck medicine at USC. Petrigliano’s research focus is on developing stem-cell based therapies to treat ligament and cartilage injury. He is a renowned orthopedic sports medicine physician and surgeon sought out for his skills and expertise, and his kindness. Contact him at his Los Angeles, CA office to schedule a consultation today.

At a Glance

Dr. Frank Petrigliano

  • Associate Professor of Orthopaedic Surgery at USC
  • Chief of the Epstein Family Center for Sports Medicine
  • Team physician for the LA Kings and USC Athletics
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