The basic focus of our lab is the study of the underpinnings of muscle atrophy and degeneration following large rotator cuff tears.
Following rotator cuff repair, muscle atrophy and fibrosis may result in persistent weakness and increase the risk of repair failure. Consequently, our team is studying cutting-edge approaches to improve rotator cuff function via the delivery of stem cells that are specialized to restore muscle after chronic injury.
This work has been funded by the National Institutes of Health and the Orthopaedic Research and Education Foundation, and a recent study was awarded the Charles S. Neer Award in recognition of outstanding work in the field of shoulder research. We also work in close collaboration with the Eveseenko Lab at the University of Southern California developing small molecule and stem cell-based therapies to treat osteoarthritis.
The ultimate goal of our work is to provide novel treatments that improve function and decrease the risk of arthritis after shoulder injury.
Most Recent Publications:
Jensen AR, Kelley BV, Mosich GM, Ariniello A, Eliasberg CD, Vu B, Shah P, Devana SK, Murray IR, Péault B, Dar A, Petrigliano FA. Neer Award 2018: Platelet-derived growth factor receptor α co-expression typifies a subset of platelet-derived growth factor receptor β-positive progenitor cells that contribute to fatty degeneration and fibrosis of the murine rotator cuff. J Shoulder Elbow Surg. 2018 Jul;27(7):1149-1161. doi: 10.1016/j.jse.2018.02.040. Epub 2018 Apr 10. PMID: 29653843
Shkhyan R, Van Handel B, Bogdanov J, Lee S, Yu Y, Scheinberg M, Banks NW, Limfat S, Chernostrik A, Franciozi CE, Alam MP, John V, Wu L, Ferguson GB, Nsair A, Petrigliano FA, Vangsness CT, Vadivel K, Bajaj P, Wang L, Liu NQ, Evseenko D. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 May;77(5):760-769. doi: 10.1136/annrheumdis-2017-212037. Epub 2018 Feb 7. PMID: 29436471
Eliasberg CD, Dar A, Jensen AR, Murray IR, Hardy WR, Kowalski TJ, Garagozlo CA, Natsuhara KM, Khan AZ, McBride OJ, Cha PI, Kelley BV, Evseenko D, Feeley BT, McAllister DR, Péault B, Petrigliano FA. Perivascular Stem Cells Diminish Muscle Atrophy Following Massive Rotator Cuff Tears in a Small Animal Model. J Bone Joint Surg Am. 2017 Feb 15;99(4):331-341. doi: 10.2106/JBJS.16.00645 PMID: 28196035
Complete List of Publications: